Prof. Dr. med. Johannes Schödel D. phil.
Oberarzt, Facharzt für Innere Medizin, Facharzt für Innere Medizin und Nephrologie, Zusatzbezeichnungen für Internistische Intensivmedizin und Transplantationsmedizin
Education, Training and Academic Positions
Publications
- (2024) Analyzing longitudinal trait trajectories using GWAS identifies genetic variants for kidney function decline. Nat Commun. 2024;15(1):
- (2023) Hypoxia controls expression of kidney-pathogenic MUC1 variants. Life Sci Alliance. 2023;6(9):
- (2023) Hypoxia induces polycystin-1 expression in the renal epithelium. R Soc Open Sci. 2023;10(5):
- (2023) Hypoxia hits APOL1 in the kidney. Kidney Int. 2023;104(1): 53-60
- (2023) KidneyGPS: a user-friendly web application to help prioritize kidney function genes and variants based on evidence from genome-wide association studies. BMC Bioinformatics. 2023;24(1):
- (2023) Hypoxia and renal fibrosis. Am J Physiol Cell Physiol. 2023;325(4): C999-C1016
- (2023) CRISPR Activator Approaches to Study Endogenous Androglobin Gene Regulation. Methods Mol Biol. 2023;2648(): 167-185
- (2022) The renal cancer risk allele at 14q24.2 activates a novel hypoxia-inducible transcription factor-binding enhancer of DPF3 expression. J Biol Chem. 2022;298(3):
- (2022) Loss of Polycystin-1 causes cAMP-dependent switch from tubule to cyst formation. iScience. 2022;25(6):
- (2021) Androglobin gene expression patterns and FOXJ1-dependent regulation indicate its functional association with ciliogenesis. J Biol Chem. 2021;296():
- (2021) Significance of Glomerular Immune Reactivity in Time Zero Biopsies for Allograft Survival Beyond IgA. Front Med (Lausanne). 2021;8():
- (2020) Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)-mediated induction of the long noncoding RNA NICI. J Biol Chem. 2020;295(13): 4065-4078
- (2020) Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression. Haematologica. 2020;105(12): 2774-2784
- (2020) Molecular diagnosis of kidney transplant failure based on urine. Am J Transplant. 2020;20(5): 1410-1416
- (2020) Macrophage migration inhibitory factor is regulated by HIF-1α and cAMP and promotes renal cyst cell proliferation in a macrophage-independent manner. J Mol Med. 2020;98(11): 1547-1559
- (2019) Now a Nobel gas: oxygen. Pflugers Arch. 2019;471(11-12): 1343-1358
- (2019) Mechanisms of hypoxia signalling: new implications for nephrology. Nat Rev Nephrol. 2019;15(10): 641-659
- (2019) Hypercalcemia mimicking myocardial infarction. Kidney Int. 2019;96(6): 1428-1428
- (2017) Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway. PLoS Genet. 2017;13(7): e1006872
- (2017) Posttranscriptional Regulation of LOXL1 Expression Via Alternative Splicing and Nonsense-Mediated mRNA Decay as an Adaptive Stress Response. Invest Ophthalmol Vis Sci. 2017;58(13): 5930-5940
- (2017) Pseudoexfoliation syndrome-associated genetic variants affect transcription factor binding and alternative splicing of LOXL1. Nat Commun. 2017;8(): 15466
- (2016) Hypoxia-inducible Factor Crosses the Checkpoint. Eur Urol. 2016;70(4): 633-634
- (2016) P2Y2R is a direct target of HIF-1? and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells. Purinergic Signal. 2016;12(4): 687-695
- (2016) Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer Nat Commun. 2016;7(): 13183-
- (2015) Hypoxia and hypoxia-inducible factors in myeloid cell-driven host defense and tissue homeostasis. Immunobiology. 2015;220(2): 305-314
- (2015) Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1? upon LPS Activation in the Presence of Ample Oxygen. Cell Rep. 2015;13(10): 2048-55
- (2015) Destruction of a distal hypoxia response element abolishes trans-activation of the PAG1 gene mediated by HIF-independent chromatin looping. Nucleic Acids Res. 2015;43(12): 5810-23
- (2015) Tumor hypoxia induces nuclear paraspeckle formation through HIF-2? dependent transcriptional activation of NEAT1 leading to cancer cell survival. Oncogene. 2015;34(34): 4482-90
- (2014) Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2. EMBO Rep. 2014;15(1): 70-6
- (2014) Optimal translational termination requires C4 lysyl hydroxylation of eRF1. Mol Cell. 2014;53(4): 645-54
- (2014) ANALYSES OF HYPOXIA INDUCIBLE TRANSCRIPTION FACTOR DNA-BINDING AND HYPOXIC GENE REGULATION IN PRIMARY HUMAN RENAL TUBULAR CELLS Nephrol Dial Transplant. 2014;29 3(): 330-330
- (2012) Selective stabilization of HIF-1? in renal tubular cells by 2-oxoglutarate analogues. Am J Pathol. 2012;181(5): 1595-606
- (2012) Renal Tubular HIF-2? Expression Requires VHL Inactivation and Causes Fibrosis and Cysts. PLoS ONE. 2012;7(1): e31034
- (2011) Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1? (HIF1A) and result in differential HIF1A-dependent gene expression. J Leukoc Biol. 2011;90(3): 551-62
- (2011) Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury. J Am Soc Nephrol. 2011;22(11): 2004-15
- (2010) The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1. J Biol Chem. 2010;285(9): 6658-69
- (2010) Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1. FASEB J. 2010;24(11): 4443-58
- (2010) Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells. Kidney Int. 2010;78(9): 857-67
- (2009) HIF-1 or HIF-2 induction is sufficient to achieve cell cycle arrest in NIH3T3 mouse fibroblasts independent from hypoxia. Cell Cycle. 2009;8(9): 1386-95
- (2009) HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury. Am J Pathol. 2009;174(5): 1663-74
- (2009) Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model. Proc Natl Acad Sci U S A. 2009;106(50): 21276-81
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